Bridging the Gap Between the Academic and Non-Profit World to Ensure Effective Diagnostic Testing for All. At the MIT Global Challenge: http://globalchallenge.mit.edu/teams/view/208

1. Innovation in Diagnostics Initiative

2. The Promise: Point of Care Diagnostics intended for resource poor settings Many POC ideas are developed and published… But few make it out here… There is a real potential to revolutionize global healthcare, but the product pipeline needs to be addressed!

3. Problem: A Fragmented & Inefficient Translation Pipeline The Current Model Adoption & distribution Clinical validation Product development R&D Diagnostic companies Engineers PATH Depts. of Health Academic labs Funding Developed world Developing world

5. works semi-reliably

6. not field testable

7. sample prep, introduction, generally unresolved

8. not fabricated in a manufacturable way

9. all systems integrated

10. basic user interface considerations

11. constructed with eye to manufacturing needs

12. works reliably

13. ruggedized for field testing

15. Our Team: Diverse backgrounds and core strengths The Team Jennifer Li is currently a UROP in Prof. Phil Sharp's lab studying RNA splicing as well as curriculum officer for the MIT Innoworks chapter, secretary for the MIT United Allied Essential Medicines chapter, and the community service chair for the MIT Alpha Chi Omega sorority. Mobilizing students in working toward our mission and coordinating efforts in implementing the initiative. KayvanZainabadi is currently a post-doctoral fellow in the Guarente lab evaluating novel drugs for osteoporosis. He served as president of MIT's Amnesty International Chapter, co-founder of the MIT anti-genocide student group STAND, and advisory board member of the 5013(c) organization Project Rishi. Full-time staff scientist for the Innovation in Diagnostics Initiative. Ciara Lomax is an active member of MIT’s Universities Allied for Essential Medicines and is participating in a UROP with Professor OferSharone with the goal of determining the difficulties of finding jobs within the current economy and with high emphasis on technological applications. Work on the financial sustainability of the initiative, with particular focus on elucidating the market size and potential revenue streams. A.J. (Ashok) Kumar is being co-advised by Prof. George Whitesides and Prof. Bob Westervelt as he works on developing low cost diagnostic devices. A.J. speaks seTswana and has lived 50 km from Botswana. He has contacts in India with the Selco Labs, Kenya with Institute of Primate Research, Belize with Ministry of Health, and South Africa with Peace Corps. Liaison between our team and on the ground. David K. Wood is currently studying the vaso-occlusive process in sickle cell disease using microfluidics.. David is also using his knowledge of microfabrication and microfluidics to design and build point-of-care devices. Assist with product design/development and in-house testing of point-of-care technologies. Shuqi (Albert) Wang is leading the development of microchip-based POC diagnostics. Team's resident expert on POC diagnostic devices. Community Partner Clinton Health Access Initiative (CHAI) is a global health organization committed to strengthening integrated health systems in the developing world and expanding access to care and treatment for HIV/AIDS, malaria and etc. Liaison between our initiative and the Clinton Health Access Initiative. Technical adviser and expert on the feasibility and implementation of point-of-case diagnostics in the field.